What is MOTS-c?

What is MOTS-c?

MOTS-c is a 16-amino-acid mitochondrial-derived peptide. It activates the AMPK energy-sensing pathway, mimicking the metabolic signal of exercise. It is supplied for research as a pre-filled, pre-reconstituted multi-dose pen.

It is studied in metabolic and longevity research for mitochondrial function, insulin sensitivity and exercise-mimetic effects. The evidence base through 2026 is predominantly cell and animal work; research outcomes vary.

Reported side effects

• A post-dose energy crash 3–4 hours after use is the characteristic sign of dosing too high too soon — it eases when the dose is held until the body adapts.
• Fatigue or lethargy at a step the researcher has not yet acclimated to.
• Mild, transient injection-site reactions.

How to dose MOTS-c

Titrated from the lowest setting upward: start at 0.2 mg for two weeks, then step up 0.2 mg at a time (0.4, 0.6, 0.8, 1 mg) no faster than every two weeks and only when the current dose is well tolerated. Commonly taken ~30 minutes before training. The pen dials each step; no mixing.

How to get MOTS-c

MOTS-c is supplied in the UK by Body Pharm as a sealed, pre-reconstituted, HPLC-tested pen with a published Certificate of Analysis and free, discreet delivery. Sold strictly for research and analytical purposes only.

Cost per month

From £110 per pen — a single 32 mg pen covers a multi-week titration at a few doses per week.